Luckily, the stars aren't too bummed out about it -- especially Taylor, who's looking forward to putting more effort into her band The Pretty Reckless.
"The show is being very, very supportive of the band, and you physically can't do both at the same time. I can't be on set and then in France touring or wherever," Taylor says. "So they're writing me out of story lines and allowing me to tour, and I really have to thank them for that."
Vanessa Price and Jenny Humphrey aren't gone for good, though -- they're rumored to come back as guest stars next season.
Are you sad to see Vanessa and Jenny go? Or do you think it's time for their characters to leave Gossip Girl?
Photos: Courtesy of Giovanni Rufino/The CW; Kurt Iswarienko/The CW